口服葡萄糖耐量试验负荷后1h血糖与老年高血压患者左心室肥厚的关系

Correlation between one-hour postprandial hyperglycemia during oral glucose tolerance test and left ventricular hypertrophy in elderly patients with essential hypertension

  • 摘要: 目的探讨口服葡萄糖耐量试验(OGTT)1h血糖(1hPG)异常升高与老年原发性高血压患者左心室肥厚(LVH)的关系。方法老年高血压患者562例根据OGTT结果分为正常糖耐量(NGT)(n=367)、糖调节受损(IGR)(n=127)和糖尿病(DM)(n=68)组,其中NGT组根据1hPG分为1hPG≥11.1mmol/L组(n=112)和1hPG<11.1mmol/L组(n=255),超声心动图测量左心室结构相关指标,对研究资料进行Pearson相关和多因素Logistic回归分析LVH的影响因素。结果 NGT-1hPG≥11.1mmol/L组左心室质量指数(LVMI)和LVH发生率与IGR组和DM组比较差异无统计学意义(125.62±28.45)比(125.89±28.31)、(128.37±25.57)g/m2;38.39%比39.37%、42.65%,均P>0.05,但高于NGT-1hPG<11.1mmol/L组(125.62±28.45)比(112.54±26.18)g/m2;38.39%比24.71%,均P<0.05;Pearson相关分析显示NGT-1hPG<11.1mmol/L组、NGT-1hPG≥11.1mmol/L组、IGR组、DM组OGTT 1hPG与LVMI呈正相关(分别r=0.301、0.576、0.424、0.514,均P<0.01);多元线性回归分析显示,OGTT 1hPG在NGT-1hPG≥11.1mmol/L组、IGR组和DM组是LVMI的影响因素(分别B=1.268、1.250、1.316,均P<0.01)。结论在老年高血压患者中OGTT 1hPG与LVH密切相关,对OGTT 1hPG升高者应予足够的重视。

     

    Abstract: Objective To explore the association between 1hpostprandial hyperglycemia during oral glucose tolerance test(OGTT)and left ventricular hypertrophy(LVH)in elderly patients with essential hypertension(EH).Methods A total of 562 elderly patients with EH were enrolled. All patients underwent OGTT for the evaluation of glucose tolerance. According to the OGTT results,patients were divided into normal glucose tolerance group(NGT,n=367),impaired glucose regulation group(IGR,n=127)and type 2diabetes group(DM,n=68).Based on the 1-h postload plasma glucose(1hPG)cutoff point of 11.1mmol/L,NGT subjects were divided into two groups:NGT-1hPG<11.1mmol/L(n=255)and NGT-1hPG≥11.1mmol/L(n=112)group. The indicators related to left ventricular structure were measured by echocardiography. Pearson correlation and multiple linear regression analysis were performed to assess the influencing factors of LVH. Results The left ventricular mass index(LVMI)and LVH prevalence in the NGT-1hPG≥11.1 mmol/L group were not different from those in IGR group or DM group (125.62±28.45)vs(125.89±28.31),(128.37±25.57)g/m2;38.39% vs 39.37%,42.65%,all P>0.05,but were significantly higher than those in NGT-1hPG<11.1mmol/L group(125.62±28.45)vs(112.54±26.18)g/m2;38.39% vs 24.71%,both P<0.05. Pearson correlation analysis showed that OGTT1 hPG was positively correlated with LVMI in NGT-1hPG<11.1 mmol/L,NGT-1hPG≥11.1 mmol/L,IGR and DM group(r=0.301,0.576,0.424,0.514,respectively,all P<0.01). Multiple linear regression analysis indicated that OGTT 1hPG was independently correlated with LVMI in NGT-1hPG≥11.1mmol/L,IGR and DM groups(B=1.268,1.250,1.316,respectively,all P<0.01). Conclusion OGTT 1hPG is closely correlated with LVH in elderly patients with EH. Enough attention should be paid to those subjects with increased OGTT 1hPG.

     

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