老年人卧位血压与尿微量白蛋白的相关性

The correlation of supine blood pressure with urine microalbumin in the elderly

  • 摘要: 目的探讨老年人卧位血压与尿微量白蛋白的关系。方法在参加开滦研究第3次健康体检的人群中,采取整群抽样的方法抽取年龄≥60岁的开滦集团离退休员工3064人,其中符合入选标准纳入统计分析者1692人。采用偏相关分析坐位、卧位、立位收缩压,舒张压与尿微量白蛋白的相关性,多因素Logistic回归分析卧位高血压对尿微量白蛋白的影响。结果观察对象1692人(男性1122人,女性570人),年龄为(67.3±6.2)岁,尿微量白蛋白为(25.9±43.5)mg/L。校正年龄、性别后,坐位、卧位、立位即刻、立位3min收缩压、舒张压均与尿微量白蛋白呈正相关。多因素Logistic回归分析显示:校正了年龄、性别等混杂因素后,坐位、卧位高血压是尿微量白蛋白增加的危险因素(坐位:OR=1.66,95%CI1.23~2.24;卧位:OR=1.48,95%CI 1.14~1.92),而立位高血压、立位低血压的相关性无统计学意义;坐位高血压、立位高血压、立位低血压、卧位高血压同时代入方程,并校正其他相同变量,坐位高血压是尿微量白蛋白增加的独立危险因素(OR=1.44,95%CI1.01~2.07),而卧位高血压、立位高血压、立位低血压的相关性无统计学意义。结论老年人坐位高血压与尿微量白蛋白增加相关性最大,卧位高血压次之,立位高血压或立位低血压与尿微量白蛋白增加相关性无统计学意义。

     

    Abstract: Objective To investigate the correlation of the supine blood pressure with urine microalbumin in an elderly population. Methods From the employees of Kailuan group who participated the third physical examination,3064 retired employees with age of more than sixty years were randomly selected using the cluster sampling method.Among them,1692 met the inclusion criteria and were enrolled into the study. Rank correlation and partial correlation analysis were used to analyze the correlation of supine,standing and sitting systolic blood pressure(SBP)and diastolic blood pressure(DBP)with urine microalbumin. Multivariate Logistic regression analysis was used to analyze the influence of supine hypertension on urine microalbumin. Results The age of 1692participants(males:1122;females:570)was(67.3±6.2)years old,and urine microalbumin was(25.9±43.5)mg/L. The supine,standing and sitting SBP and DBP were correlated with urine microalbumin after adjusted for age and gender. Multiple Logistic regression analysis showed that after adjusted for age,gender and other factors,supine and sitting hypertension were risk factors for increased urine microalbumin(supine:OR=1.48,95% CI 1.14-1.92;sitting:OR=1.66,95% CI1.23-2.24,respectively). However,orthostatic hypotension and orthostatic hypertension were not associated with urine microalbumin. When entered any of them in the analysis model,and adjusted for the same confounding factors,we found that only sitting hypertension was the most significant risk factor for increased urine microalbumin(OR=1.44,95% CI1.01-2.07). Conclusion Sitting hypertension was the most significant risk factor of increased urine microalbumin in elderly population,and supine hypertension came second. Orthostatic hypotension and orthostatic hypertension were not associated with microalbumin.

     

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