Abstract: Objective To explore the relationship between alcohol dependence and blood pressure control in patients with hypertension in Xuzhou. Methods Essential hypertensive patients with regular treatment were extracted by multi-stage stratified cluster random sampling method between April to June 2013 in Xuzhou. The degree of alcohol dependence was measured with Michigan alcoholism screening test（MAST）,and other factors were investigated by self-designed questionnaire. The participants were divided into three groups,which was teetotal group,non-alcohol-dependent group and alcohol-dependent group. And the alcohol-dependent group was subdivided into low,mild,moderate and above degree subgroup.Results A total of 4405 hypertensive patients were included. The mean systolic blood pressure and diastolic blood pressure were（143.0±16.8）and（88.0±10.9）mm Hg,respectively. The drinking rate was 16.5%（95% CI15.4%-17.6%）,and the rate of alcohol dependence was 13.8%（95% CI12.8%-14.9%）. A total of 1259 patients had their blood pressure controlled,and the rate of blood pressure control was 28.6%（95% CI 27.3%-29.9%）. Non-alcohol-dependent group had the highest rate of blood pressure control（40.7%）,and alcohol-dependent group had the lowest rate of blood pressure control（25.9%）,while the rate of blood pressure control in teetotal group was 28.6%（χ~2=10.67,P＜0.01）. There were no statistically significant differences in the rate of blood pressure control among the subgroups with different degree of alcohol dependence（χ~2=0.06,P=0.97）. Compared to the teetotal group,Logistic regression analysis showed that the OR was increased with increase in the degree of alcohol dependencepatients with non-alcohol-dependence（OR=0.59,95% CI0.40-0.85,P＜0.01）,low dependence（OR=1.90,95% CI1.17-3.09,P＜0.01）,mild dependence（OR=1.99,95% CI 1.27-3.13,P＜0.01）,moderate and above dependence（OR=2.00,95% CI1.17-3.41,P＜0.01）. After adjusting for confounding factors,such as age,body mass index,education level,physical exercise and income level,alcohol dependence was still an adverse factor for blood pressure controlnon-alcohol-dependence（OR=0.59,95% CI0.41-0.86,P＜0.01）,low dependence（OR=1.89,95% CI1.16-3.09,P＜0.01）,mild dependence（OR=1.96,95% CI1.25-3.10,P＜0.01）,moderate and above dependence（OR=1.98,95% CI1.15-3.39,P＜0.01）. Conclusion Alcohol independence is good for blood pressure control,while alcohol dependence is bad for blood pressure control in patients with hypertension.