Abstract:
Objective To explore the relationships between serum fibroblast growth factor 21(FGF21),adiponectin and coronary heart disease(CHD). Methods A total of 375 patients were recruited between June 2013 and June2014,including 232 patients with CHD(CHD group)and 143 patients without CHD(non-CHD group). The mean age of the participants was(63.3±9.8)years old. The levels of serum FGF21 and adiponectin were measured by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the relationships between serum FGF21,adiponectin and CHD. Results Compared with non-CHD group,proportion of male,smoking and diabetes mellitus,age,waist to hip ratio,fasting glucose,glycosylated hemoglobin(HbA1c)levels were higher,and FGF21(357.5±14.0)vs(419.2±17.0)ng/L,adiponectin(6.5±0.5)vs(8.1±0.8)mg/Lwere lower in CHD group(all P<0.05). Partial correlation analysis showed that serum FGF21 level was negatively correlated with the Gensini score(r=-0.128,P<0.05)and the lesion number in the coronary artery(r=-0.104,P<0.05). However,there was a positive association between FGF21 and adiponectin in Spearman correlation analysis(r
s=0.200,P<0.05). After adjustment for sex,age,smoking,HbA1 c,high-density lipoprotein cholesterol(HDL-C)and homeostasis model assessment of insulin resistance,multivariate Logistic regression analysis revealed that HDL-C(OR=0.368,P<0.05)and FGF21(OR=0.376,P<0.05)were the protective factors for CHD; age(OR=1.032,P<0.05),HbA1c(OR=2.038,P<0.01)and smoking(OR=1.999,P<0.05)were the risk factors for CHD. Conclusion Serum FGF21 is one of the protective factors for CHD,and it is positively correlated with adiponectin,while negatively correlated with the Gensini scores and the number of coronary artery lesions.