Abstract: Objective To explore the origin of arterial sound and blood pressure auscultation sound by heart-sound sensor. Methods Firstly,the synchronization sound graph of heart and brachial artery（or carotid artery）at the time of blood pressure measuring or not was recorded respectively after one heart sound sensor was attached to the strongest beating place of the precordial region,and the other sensor was attached to the blood pressure auscultation place of right brachial artery（or the strongest impulse place of carotid artery）. Secondly,the synchronization sound graph of right brachial artery and carotid artery was recorded after one heart sound sensor was attached to the strongest impulse place of the carotid artery,and the other sensor was attached to the blood pressure auscultation place of right brachial artery. Results The waveform of arterial main-peak and the waveform group of first heart sound occurred simultaneously. The waveform of arterial post-peak and the waveform group of second heart sound occurred simultaneously. The waveform of blood pressure auscultation sound appeared on the place of the mainpeak waveform. Conclusion The arterial main-peak sound,the blood pressure auscultation sound and the first heart sound were homologous,they all originated from the atrioventricular valves which generated vibration at the time of shutting. The arterial post-peak sound and the second heart sound were homologous,they both originated from the aortic/pulmonary valves which generating vibration at the time of shutting.