中国3~17岁儿童性别、年龄别和身高别血压参照标准

Updating blood pressure references for Chinese children aged 3-17 years

  • 摘要: 目的对2010年发布的中国儿童性别和年龄别血压标准(2010年标准)进行更新,制定性别、年龄别和身高别的儿童血压参照标准(更新标准)。方法参照人群同2010年标准,共纳入儿童106 123人。血压测量采用水银血压计,以Korotkoff音第1音为收缩压,第5音为舒张压。采用位置、形状和范围的广义相加模型(GAMLSS),计算不同性别、年龄别及身高别对应的第50、90、95和99百分位(P50、P90、P95和P99)血压值。采用一组独立的儿童血压现况调查数据(n=43 476,6~17岁,男性占51.2%)验证新旧标准的一致性。结果更新标准的血压切点值(P50、P90、P95和P99)随年龄及身高增加而增加。与2010年标准相比,更新标准明显降低了身高P5对应收缩压-P95值,其中男童降低3~7、女童降低0~6mm Hg;更新标准明显抬高了身高P95对应收缩压-P95值,其中,男童升高2~6、女童升高0~4mm Hg;更新标准只降低了3~13岁男女身高P5对应舒张压-P95值;更新标准身高P95对应舒张压-P95值与2010年标准无明显差异。2010年标准诊断的高血压儿童中,用更新标准确诊为高血压的比例为90.1%。结论更新标准同时考虑了性别、年龄和身高因素,可更准确评估儿童血压水平。

     

    Abstract: Objective To develop blood pressure(BP)references by age and height simultaneously for Chinese children aged 3-17years(updating references). Methods Based on a pooled sample of 106 123 children,BP values were obtained with certified mercury sphygmomanometers by trained examiners. Systolic BP(SBP)and diastolic BP(DBP)were defined by Korotkoff sounds phase 1and phase 5,respectively. The sex-,age-and height-specific BP percentiles(P50,P90,P95 and P99)were calculated by the generalized additive model for location scale and shape(GAMLSS). Data on BP were available for a total of 43 476 children aged 6to 17years(male:51.2%)from a separate survey and the difference in the discrimination ability of hypertension between updating references and BP references in 2010 was studied. Results The cut-off values(P50,P90,P95 and P99)of BP increased with height and age.Compared to BP references in 2010,SBP level of the 95 th percentiles of updating references at the height of5 th percentiles was lower(lowered by 3-7mm Hg in male and 0-6mm Hg in female);SBP level of the 95 th percentiles of updating references at the height of 95 th percentiles was higher(increased by 2-6mm Hg in male and 0-4mm Hg in female);DBP level of the 95 th percentiles of updating references at the height of 5th percentiles from 3to 13 years was lower;DBP level of the 95 th percentiles of updating references at the height of 95 th percentiles was similar.Among hypertensive children defined by BP references in 2010,90.1%remained hypertensive according to updating references. Conclusion The BP references by age and height are useful for identifying hypertensive children.

     

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