Abstract: Objective To investigate the relationships between ten single nucleotide polymorphisms（SNP）of peroxisome proliferators-activated receptor（PPAR）α/δ/γgenes and mean arterial pressure（MAP）. Methods A total of 820 subjects from "the prevention of metabolic syndrome and multi-metabolic disorders in Jiangsu province of China study（PMMJS）" were included,which was composed of 550 females and 270 males. Ten SNP of PPARα/δ/γgenes were selected according to the following criteria:（1）minor allele frequency（MAF）≥0.05;（2）reported the association with metabolic syndrome,and（3）locus at functional region or possible occurrence of mutation lying in the area. The association between SNP and MAP was analyzed. Results Hardy-Weinberg equilibrium analysis was used to evaluate ten SNP of PPARα/δ/γgenes,showing that all of selected SNP satisfied Hardy-Weinberg equilibrium（P＞0.05）. Multiple linear regression analysis showed that compared to the persons with wild genotype of PPAR genes,the MAP levels in subjects with mutant genotype of rs135539 in PPARα（A/C-C/C）and rs9794 in PPARδ（C/G-G/G）decreased 2.212（95% CI-3.715 to-0.711）mm Hg and 1.580（95% CI-3.121 to-0.068）mm Hg,respectively. However,the mean level of MAP in the subjects with mutant genotype of rs10865710 in PPARγgenes（C/G-G/G）increased 1.601（95% CI 1.018 to 3.021）mm Hg,all P ＜0.05.Conclusion rs135539 of PPARαgene,rs9794 of PPARδgene and rs10865710 of PPARγgene are significantly associated with MAP levels.