Abstract: Objective To investigate the association of systolic blood pressure and resting heart rate with new-onset diabetes. Methods The staff from Kailuan Group Company who participated in the health examination in 2006-2007 and had no history of diabetes were selected as the subjects. The second,third,and fourth health examinations were conducted in 2008-2009,2010-2011 and 2012-2013,respectively. The subjects were divided into 16 groups according to different levels of systolic blood pressure（≤120,121-140,141-160,＞160 mm Hg）and resting heart rate（≤60,61-70,71-80,＞80 beats/min）. The incidence of new-onset diabetes among these 16 groups were compared,and the risk of diabetes was analyzed using multivariable Cox regression analysis. Results A total of 69 048 subjects were involved in the final statistical analysis and 5931 subjects developed diabetes during the follow-up of 6 years,with the incidence rate of 8.6%. The incidence rate of diabetes increased with the increase of resting heart rate and systolic blood pressure,and which was the highest（18.0%）in the group with systolic blood pressure＞160 mm Hg and resting heart rate＞80 beats/min,and was the lowest（4.6%）in the group with systolic blood pressure ≤120 mm Hg and resting heart rate ≤60 beats/min. Multivariable Cox regression analysis showed that the risk of diabetes in the group with systolic blood pressure ＞160 mm Hg and resting heart rate＞80 beats/min was 2.88 times（95% CI2.26-3.66）higher than that in the group with systolic blood pressure≤120 mm Hg and resting heart rate≤60 beats/min after adjusting for age,gender,body mass index and other confounders at baseline. Conclusion Increased systolic blood pressure and resting heart rate could increase the risk of diabetes.