Abstract: Objective To observe the changes of bone mineral density（BMD）in patients with hypertension and diabetes mellitus,and to explore the correlation between BMD and metabolic disorders such as hypertension and hyperglycemia. Methods A total of 561 subjects were divided into 4 groups:108 cases in normal group,101 cases in hypertension group,183 cases in diabetic group and 169 cases in diabetic and hypertension group. Blood pressure,blood glucose,blood lipids were measured,body mass index（BMI）was calculated,and bone metabolism markers were detected. Dual energy X-ray absorptiometry was used to detect anteroposterior spine and femur BMD.Results In the normal group,the incidence of abnormal bone metabolism（osteopenia+osteoporosis）was 25.0%.In the hypertension group,the incidence of abnormal bone metabolism was 38.6%.In the diabetic group,the incidence of abnormal bone metabolism was 47.5%. While in the diabetic and hypertensive group,the incidence of abnormal bone metabolism was 54.4%（χ~2=25.43,P＜0.01）. According to multivariate stepwise regression analysis,age,total cholesterol（Tch）,and hemoglobin A1c（HbA1c）were negatively correlated with BMD of anteroposterior spine,while BMI and serum uric acid were positively correlated with BMD of anteroposterior spine. Age,Tch,type 1 collagen cross-linked C-telopeptide（CTX）was negatively correlated with femur BMD,and BMI was positively correlated with femur BMD. Diastolic blood pressure was positively correlated with anteroposterior spine BMD and femoral BMD but not independently. Conclusion Age,Tch,HbA1c,serum uric acid and CTX were the risk factors of osteoporosis.BMI was positively correlated with spine BMD and femoral BMD. Diastolic blood pressure was correlated with anteroposterior spine BMD and femoral BMD,but not independent.