高血压对老年人日常活动能力影响的队列研究

Effect of hypertension on activities of daily living in Chinese elderly population: a cohort study

  • 摘要: 目的探讨高血压及高血压合并其他慢性病数目对中国老年人日常活动能力(ADL)受损风险的影响。方法将中国老年健康影响因素跟踪调查(CLHLS)2002年募集的未发生ADL受损的老年人10 563人的调查信息作为基线数据,基线数据主要包括老年人的个体特征、高血压和其合并慢性病数目情况,并将这些老年人分为不患任何慢性病、1种慢性病(指不包括高血压的慢性病)、≥2种慢性病、单纯高血压、高血压合并1种慢性病、高血压合并≥2种慢性病,共6个亚组。该老年队列人群ADL受损结局分别于2005、2008、2011、2014年进行随访。采用Cox比例风险模型分析高血压及合并其他慢性病对老年人ADL受损风险的影响。结果老年人10 563人中,基线调查时老年人患高血压1 577例(14.92%),随访结束时老年人出现ADL受损2 131例(20.17%),队列观察结束时ADL完好的累积概率为40.03%。调整混杂因素影响后,与不患慢性病的老年人相比,年龄≥65岁老年人单纯高血压可增加ADL受损风险38%(HR=1.38,95%CI 1.14~1.68),高血压合并1种慢性病增加ADL受损的风险42%(HR=1.42,95%CI 1.17~1.71),高血压合并≥2种慢性病增加ADL受损风险54%(HR=1.54, 95%CI 1.28~1.86),ADL受损风险随着高血压合并慢性病数量的增加而升高,并存在剂量反应关系(回归系数为0.09,P<0.001)。结论高血压是导致老年人ADL受损的重要危险因素;高血压合并慢性病数增加导致ADL受损风险升高。

     

    Abstract: Objective To explore the effects of hypertension and the number of combined chronic diseases on the risk of impaired daily activities(ADL) in Chinese elderly. Methods Survey data of 10 563 elderly people without ADL impairments recruited by the Chinese longitudinal healthy longevity survey(CLHLS) in 2002 was used as baseline data, which included the individual characteristics of the elderly and hypertension and the number of combined chronic diseases. These data were then divided into 6 groups: no chronic disease, 1 chronic disease(excepted of hypertension) group, ≥2 chronic diseases, hypertension only, hypertension combined with one chronic disease, hypertension combined with ≥2 chronic diseases. The ADL were followed up every 3 years in 2005, 2008, 2011 and 2014. Cox proportional hazard model was used to estimate the hazards ratios(HR) for the associations between hypertension and the risk of ADL impairment. Results Among the 10 563 elderly people, 1 577(14.92%) had hypertension at the baseline survey. At the end of the follow-up, 2 131(20.17%) had ADL impairment, and the cumulative probability of well ADL was 40.03%. After adjusting for the effects of confounding factors, compared with the elderly without chronic diseases, the risk of ADL impairment was increased by 38%(HR=1.38, 95% CI 1.14-1.68) in hypertension only group, 42%(HR=1.42, 95% CI 1.17-1.71) in hypertension combined with 1 chronic disease group, 54%(HR=1.54, 95% CI 1.28-1.86) in hypertension combined with ≥2 chronic diseases group. The piecewise linear regression coefficient of dose response was 0.09(P<0.001). Conclusion Hypertension is an important risk factor for the impairment of ADL in the elderly. With the increase of the number of combined chronic diseases, the risk of ADL impairment increased gradually.

     

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