Abstract: Objective To investigate the relationship between arterial stiffness and 10-year atherosclerotic cardiovascular disease（ASCVD） risk predicted by the models of Pooled Cohort Equations（PCE） or ASCVD Risk in China（China-PAR）. Methods A cross-sectional clinical study was carried out, in which clinical data were collected from 1 090 subjects aged 30-75 years who were admitted to the departments of general medicine or geriatrics of the First Affiliated Hospital of Fujian Medical University from February 2016 to December 2018. Arterial stiffness was examined by carotid-femoral pulse wave velocity（cfPWV）. All subjects were divided into two groups: normal arterial stiffness（cfPWV＜10 m/s） and elevated arterial stiffness（cfPWV≥10 m/s）. Ten-year ASCVD risk was predicted by either PCE or China-PAR. Results ASCVD risks predicted by two models in the group of elevated arterial stiffness were higher than those in the group of normal arterial stiffness PCE: 16.5%（8.6%-28.3%） vs 6.3%（2.7%-12.3%）;China-PAR: 8.8%（6.1%-12.4%） vs 3.9%（2.1%-6.6%）, both P＜0.001. The correlation coefficient between cfPWV and ASCVD risk predicted by China-PAR was greater than that by PCE（0.573 vs 0.503, z=5.272, P＜0.001）. Multivariate linear regression analysis showed that 10-year ASCVD risk predicted by PCE model（β=0.475, P＜0.001） and waist circumference（β=0.092, P=0.001） correlated with cfPWV. However, when PCE model was replaced with China-PAR, only ASCVD risk（β=0.573, P＜0.001）, not waist circumference, was associated with arterial stiffness. Receiver operation characteristic curve showed that the discrimination of 10-year ASCVD risk predicted by China-PAR for arterial stiffness was better than PCE（area under curve 0.814 vs 0.767, z=4.992, P＜0.001）. Stratification analysis displayed that the better discrimination by China-PAR mainly came from male. Conclusion Ten-year ASCVD risks predicted by China-PAR or PCE are both associated with arterial stiffness. The association is stronger when the risk is predicted by China-PAR, especially in males.