Abstract: Objective To observe the effect of angiotensin-converting enzyme inhibitor（ACEI） and angiotensin receptor blocker（ARB） on the outcome of hospitalization in patients with hypertension and novel coronavirus pneumonia（NCP）. Methods Retrospective analysis was performed. In 202 NCP patients who were hospitalized in Thunder-God hospital, Wuhan from February 12, 2020 to March 30, 2020, 67（33.0%） complicated with hypertension. According to whether taking ACEI or ARB, 67 patients were divided into 3 groups. Patients who received ACEI or ARB during treatment were included in group A（n=22）. Patients who received ACEI or ARB before admission but interrupted ACEI or ARB after admission were included in group B（n=24）. Patients who were not treated with ACEI or ARB before and after admission were included in group C（n=21）. Therapeutic indicators such as the use of antiviral drugs, anti-hypertensive drugs, oxygen therapy, blood pressure control levels and hospitalization outcomes such as average days of hospitalization, hospitalization mortality rate, grade of deterioration during hospitalization, and some serum biochemical indicators such as alanine aminotransferase（ALT）, lactate dehydrogenase（LDH）, creatinine（Cr） and creatine kinase（CK） were recorded. The changes of these indicators in the three groups of patients and their application relationship with ACEI/ARB were compared and analyzed. Results There was no significant difference in age, gender, blood pressure level, underlying disease, severity（common type, ratio of severe to critical）, and serum biochemical indicators（ALT, LDH, creatinine, creatine kinase levels） at admission among three groups（all P＞0.05）. During the hospitalization, there were no statistically significant differences in the proportion of NCP-related medication use, oxygen therapy, hospital mortality, recovery and discharge rate, the degree of deterioration during hospitalization and the days of throat swab nucleic acid turning negative among three groups（all P＞0.05）. Compared with the group A, the proportion of calcium channel blocker in the group B and the group C was higher（95.8%, 85.7% vs 40.9%, P＜0.01）, but there was no significant difference in blood pressure levels and compliance rates at discharge（P＞0.05）. Compared with the group A, the hospitalization period of the group B and the group C was longer （30.04±8.82）,（30.09±9.25） vs（27.41±6.43） d, but the difference was not statistical significance（all P＞0.05）. Compared with admission, there was no statistically significant difference in serum ALT, LDH, creatinine and creatine kinase levels among the three groups during hospitalization（all P＞0.05）. Conclusion ACEI or ARB has no significant effect on the outcome of hospitalization in patients with hypertension and NCP.