Abstract: Objective To investigate the relationship between essential hypertension（EH）and bone mineral density in postmenopausal females. Methods This research was based on the REACTION study（clinical study on risk factors of type 2 diabetes mellitus and cancer risk）initiated by Chinese Medical Association in 2011. From July to December 2011,a total of 715 eligible postmenopausal females aged over 40 years were collected from the community residents in Dalian area. They performed the physical examination of bone mineral density and had hypertension but did not use antihypertensive drugs. According to the bone mineral density,these subjects were divided into normal bone mass group（350 cases）,osteopenia group（268 cases）and osteoporosis group（97 cases）. The detection rate of hypertension and blood pressure of the three groups were compared. The correlation between blood pressure and the T scores of lumber spine bone mineral density（BMDTs）was analyzed. Results Systolic pressure and pulse pressure in normal bone mass group,osteopenia group,osteoporosis group increased in turn（F=6.010,P＜0.05）. There was no significant difference in diastolic pressure among the three groups（P ＞0.05）. Systolic blood pressure,rather than diastolic blood pressure was negatively correlated with BMDTs（r =-0.087,P=0.020）. After adjusting for age,height,body mass,hip circumference,triglyceride and menopause years,systolic blood pressure was negatively correlated with BMDTs（β=-0.007,P=0.013）,as indicated by multiple stepwise linear regression analysis which BMDTs was the dependent variable. Conclusion Systolic blood pressure is an independent risk factor of osteoporosis in postmenopausal females.