细颗粒物长期暴露对高血压影响的荟萃分析与系统评价

The effects of long-term exposure to fine particulate matter on hypertension:a meta-analysis and system review

  • 摘要: 目的系统评价长期暴露于细颗粒物(PM2.5)空气污染对成人高血压发病风险的影响。方法通过检索中国知网、万方数据库、PubMed、Embase、Cochrane Library等数据库中发表的PM2.5长期暴露对高血压影响的队列研究(以上文献检索截至2020年11月)。提取风险比(HR)及其95%CI以评估关联的强度,还进行了亚组分析和敏感性分析。结果最终共有7项研究被纳入分析,总体荟萃分析发现长期PM2.5暴露导致高血压的发病风险增加,每增加10μg/m3暴露浓度HR=1.11,95%CI 1.05~1.17。通过亚组分析发现,年龄≥50岁人群和绝经后女性可能是长期PM2.5暴露导致高血压的高危人群,但本研究没有发现中国和北美地区人群、不同性别的人群在该发病风险上有差异。结论长期PM2.5暴露和高血压的发生存在正相关。

     

    Abstract: Objective To systematically evaluate the effect of long-term exposure to fine particulate air pollution on the incidence of hypertension in adults. Methods The cohort studies on the effects of long-term exposure to fine paticulate matter(PM2.5) on hypertension published in China national knowledge infrastructure(CNKI), Wanfang database, PubMed, Embase, Cochrane Library and other databases were searched(the literature retrieval was up to November 2020). Hazard ratio(HR) and its 95%CI were extracted to assess the strength of the association. Subgroup analysis and sensitivity analysis were also performed. Results Seven studies were finally included in the analysis. The overall meta-analysis found that long-term exposure to PM2.5 increased the risk of hypertension, HR=1.11, 95%CI 1.05-1.17 for each 10 μg/m~3 increase in exposure concentration. Subgroup analysis showed that the elder(≥50 years old) and menopause people may be the high-risk group, and there was no significant difference in the risk of hypertension caused by long-term PM2.5 exposure between Chinese and North American populations and different gender groups. Conclusion There is a positive correlation between long-term PM2.5 exposure and the occurrence of hypertension.

     

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