Abstract: Objective To observe the resting radial artery pulse wave of patients with long-term chronic diseases who have been routinely treated and intensively managed by the holistic program of individualized exercise. Methods Twenty cases of healthy people without specific exercise habits（normal group）, 20 cases of long-term chronic disease patients who only received routine treatment and did not receive intensive treatment（non-intensive trentment group）, and 20 cases of long-term chronic disease patients who received routine and intensive treatment by the holistic program of individualized exercise（intensive treatment group） were recruited from January 2019 to May 2020. The pulse wave data of their left radial artery were collected and recorded for 50 seconds. Then the similarities and differences of pulse waveforms and main indexes were analyzed qualitatively and quantitatively, including the proportion of the crest obvious dicrotic wave, main wave peak amplitude(Y_P1), dicrotic wave trough amplitude(Y_PL),dicrotic wave peak amplitude(Y_P2), main wave ascending branch slope（S₁）, dicrotic wave ascending branch slope（S₂）, dicrotic wave amplitude(Y_P2-Y_PL). Results（1）The patients received intensive treatment had similar dicrotic wave characteristics with young healthy people, and had high and narrow main wave in the radial artery pulse waveform, which was similar with young healthy people, while different from patients without intensive treatment, who had no obvious dicrotic wave characteristics, and had low and round main wave in pulse waveform.（2）Compared with young normal people, the proportion of the crest obvious dicrotic wave in patients without intensive treatment was lower, and which was higher in patients recieved intensive treatment than in patients without intensive treatment（normal group 94.7% vs non-intensive trentment group 24.5% vs intensive treatment group 95.4%, χ~2=1 810.093, P＜0.001）. Compared with young normal people, Y_P1, S₁, S₂ and Y_P2-Y_PLin patients without intensive treatment were lower and Y_PL was higher（all P＜0.05）. Compared with patients without intensive treatment, Y_P1, S₁, S₂ and Y_P2-Y_PL in patients with intensive treatment were higher and Y_PL was lower（all P＜0.05）. There was no significant difference in the above indexes between patients with intensive treatment and young normal people（all P＞0.05）. Conclusions The resting pulse wave of radial artery in patients with intensive treatment is similar to that of young normal people, the peak of the main wave is high, the amplitude of dicrotic wave is large, and the trough point is low. It is significantly different from the characteristics of long-term chronic disease patients without intensive treatment. After intensive treatment, the improvement of main wave and dicrotic wave in patients with long-term chronic disease may be used as one of the reference indexes for effective treatment of chronic disease.