Abstract: Objective To explore whether the prevalence of hypertension or blood pressure in different gender and different regions of China was related to the different grades of clean household fuels among people without antihypertensive drugs. Methods This study was based on data from the Prospective Urban and Rural Epidemiology Study in China（PURE-China Study）, which recruited participants in 12 provinces in China from 2005 to 2009, completing questionnaires and physical examinations. Finally, 38 839 participants were included for the analysis. Generalized linear mixed models were used to estimate the adjusted odds ratio（aOR） of hypertension prevalence and regression coefficients of blood pressure values, respectively. Subgroup analyses were performed for different genders and different regions（East, Central, and West）. Results Compared with the least clean household solid fuel group, cleaner fuel was significantly associated with lower hypertension prevalence and lower blood pressure liquid: hypertension, aOR=0.71,95%CI 0.57-0.88, systolic blood pressure（SBP）/diastolic blood pressure（DBP）, β（95%CI）=-4.13（-5.83,-2.42）/-1.56（-2.56,-0.55）; gas: hypertension, aOR=0.73, 95%CI 0.67-0.78, SBP/DBP, β（95%CI）=-4.51（-5.13,-3.87）/-1.42（-1.80,-1.03）; electricity: hypertension, aOR=0.57, 95%CI 0.46-0.70, SBP/DBP, β（95%CI）=-7.86（-9.49,-6.24）/-3.82（-4.82,-2.82）, respectively. A stronger and significant correlation was observed between cleaner fuel use and hypertension or blood pressure in females liquid: hypertension, aOR=0.60, 95%CI 0.46-0.79, SBP/DBP, β（95%CI）=-5.40（-7.43,-3.37）/-2.35（-3.65,-1.06）; gas: hypertension, aOR=0.69, 95%CI 0.63-0.76, SBP/DBP, β（95%CI）=-4.82（-5.56,-4.08）/-1.59（-2.07,-1.12）; electricity: hypertension, aOR=0.57, 95%CI 0.45-0.73, SBP/DBP, β（95%CI）=-7.45（-9.33,-5.57）/-4.25（-5.45,-3.05） and populations in the East regions liquid: hypertension, aOR=0.59, 95%CI 0.44-0.79, SBP/DBP, β（95%CI）=-6.09（-8.27,-3.91）/-1.94（-3.39,-0.49）; gas: hypertension, aOR=0.80, 95%CI 0.73-0.88, SBP/DBP, β（95%CI）=-2.84（-3.63,-2.05）/-1.09（-1.61,-0.57）; electricity: hypertension, aOR=0.65, 95%CI 0.47-0.89, SBP/DBP, β（95%CI）=-6.57（-9.12,-4.01）/-2.86（-4.56,-1.17）. Conclusions In Chinese populations not taking antihypertensive drugs, those using cleaner home fuel types have lower prevalence of hypertension and blood pressure levels. Cleaner household energy may reduce the burden of hypertension.