Abstract: Objective To investigate the correlation between circulating hepatokines and hypertension. Methods One hundred and ninety-six hypertensive patients poorly controlled group（114 patients） and well-controlled group（82 patients） hospitalized in the Cardiology Department of The General Hospital of Western Theater Command from October 20, 2017 to May 17, 2020, and 108 normotensive people who underwent health screening at the Cardiology Department of The General Hospital of Western Theater Command during the same period（normotensive group） were selected. Clinical data were collected from each group, and serum hepatokines were measured by protein liquid microarray assay（Merck Millipore）, including alpha-fetoprotein（AFP）, angiopoietin-like protein 3（ANGPTL3）, angiopoietin-like protein 4（ANGPTL4）, angiopoietin-like protein 6（ANGPTL6）, fibroblast growth factor 19（FGF19） and fibroblast growth factor 21（FGF21）, the basic clinical data and serum hapatokines levels were compared among the groups, and Pearson/Spearman correlation and logistic regression analyses were performed. Results Compared with the normotensive group, the poorly controlled group had lower levels of serum liver factor ANGPTL4 114.08（89.63-143.45） vs 137.34（116.49-166.17）μg/L, P＜0.001 and higher levels of FGF21 0.09（0.05-0.14） vs 0.07（0.03-0.10）μg/L, P=0.001. ANGPTL4 levels were lower in the poorly controlled group compared with the well-controlled hypertension group 114.08（89.63-143.45） vs 144.47（117.48-188.47）μg/L, P＜0.001, while ANGPTL3 levels were higher 16.46（12.08-20.21） vs 12.79（9.65-17.38）μg/L, P=0.001, with statistically significant differences. Correlation analysis showed that FGF21 was positively correlated with systolic blood pressure（r=0.129） and diastolic blood pressure（r=0.207, both P＜0.05） and ANGPTL4 was negatively correlated with systolic blood pressure（r=-0.209） and diastolic blood pressure（r=-0.157, both P＜0.05）. Multivariate logistic regression analysis showed that after correcting for fasting glucose, triacylglycerol and estimated glomerular filtration rate（eGFR）, lower ANGPTL4 was an independent risk factor for hypertension（OR=0.780, 95%CI: 0.771-0.790） and poorly controlled blood pressure（OR=0.785, 95%CI: 0.778-0.792）, lower ANGPTL3 was an independent protective factor for poorly controlled blood pressure（OR=1.080, 95%CI: 1.023-1.141）. Conclusions Serum ANGPTL4 levels are independently and negatively associated with hypertension and poorly controlled blood pressure. Serum ANGPTL3 levels are independently and positively associated with poorly controlled blood pressure.