Abstract: Objective To explore the relationship between triglyceride-glucose index（TyG） trajectory and new-onset hypertension and to provide a scientific basis for the prevention and control of hypertension. Methods The Uyghur population in the Xinjiang multiethnic cohort were used as the research object. According to the TyG level of physical examination in 2017, 2018, 2019, the TyG trajectory model was established by the SAS Proc Traj program and divided into groups. The incidence of hypertension was followed up in each group in 2020, and the association between different TyG trajectories and new-onset hypertension was analyzed using a multifactorial logistic regression model. Results A total of 7 420 patients were included, including 435 new-onset hypertension during follow-up, with an incidence of 5.86%（standard incidence of 7.51%）. Through the trajectory analysis model, three different TyG trajectory groups were finally determined: low-level-stable group, middle-level-stable group, and high-level-stable group. The incidence of hypertension increased with the increase of TyG trajectory level. The incidence of hypertension in the low-level-stable group, the middle-level-stable group, and the high-level-stable group were 3.96%, 6.34%, and 7.97%,respectively（P＜0.05）. After the multifactorial logistic regression model controlling for other factors, the incidence of hypertension in the middle-level-stable group and the high-level-stable group of TyG was 1.46 times（95%CI 1.13-1.90） and 1.61 times（95%CI 1.11-2.33） higher than that in the low-level-stable group, respectively. According to gender stratification, in women, it was found that compared with the low-level-stable group, the risk of hypertension in the middle-level-stable group and the high-level-stable group increased, but it was not found in men. The sensitivity analysis also found that compared with the low-level-stable group, the risk of hypertension in the middle-level-stable group and the high-level-stable group increased. Conclusion Uyghur population with the longitudinal trajectory level of the TyG increases the risk of hypertension.