25羟基维生素D3与高血压的因果关系及高敏C反应蛋白的中介作用：中介孟德尔随机化研究

Causal relationship between 25-hydroxyvitamin D3 and hypertension and the mediating role of high sensitivity C-reactive protein: a mediation Mendelian randomization study

    摘要
  • 摘要:
    目的  探讨25羟基维生素D3 25(OH)D3 与高血压的独立因果关联，并评估高敏C反应蛋白（hsCRP）的中介作用。
    方法 采用全基因组关联研究（GWAS）的统计数据，运用双样本孟德尔随机化（TSMR）分析方法，评估25(OH)D3与高血压的因果关联。此外，通过两步法中介分析探讨25(OH)D3与高血压关联的潜在关联是否部分通过hsCRP实现。
    结果 TSMR分析显示，25(OH)D3水平的升高可降低高血压发病风险（OR=0.975，95%CI 0.960～0.990，P=0.001）。同时，25(OH)D3与hsCRP存在负向关联（OR=0.945，95%CI 0.911～0.980，P=0.002），hsCRP与高血压存在正向关联（OR=1.018，95%CI 1.012～1.025，P=0.001）。中介效应分析进一步证实hsCRP在25(OH)D3影响高血压风险中的中介作用，效应值为−0.001 (95%CI −0.002～0)。
    结论 25(OH)D3与高血压存在因果关系，hsCRP在其中发挥了中介作用。

     

    Abstract:
    Objective To investigate the independent causal relationship between 25-hydroxyvitamin D3 25(OH)D3 and hypertension and to assess the mediating role of high-sensitivity C-reactive protein (hsCRP) in this relationship.
    Methods  Statistical data from genome-wide association studies (GWAS) were collected and a two-sample Mendelian randomization (TSMR) analysis was performed to test the causal association between 25(OH)D3 and hypertension. Additionally, a two-step mediation analysis was conducted to explore whether the potential association between 25(OH)D3 and hypertension was partially mediated through hsCRP.
    Results The TSMR analysis showed that increased levels of 25(OH)D3 could reduce the risk of hypertension (OR=0.975, 95%CI 0.960–0.990, P=0.001). Additionally, 25(OH)D3 was negatively associated with hsCRP (OR=0.945, 95%CI 0.911−0.980, P=0.002), and hsCRP was positively associated with hypertension (OR=1.018, 95%CI 1.012−1.025, P=0.001). The mediation analysis further confirmed that hsCRP mediated the effect of 25(OH)D3 on hypertension risk, with an effect value of −0.001 (95%CI −0.002 to 0).
    Conclusion There is a causal relationship between 25(OH)D3 and hypertension, with hsCRP playing a mediating role in this association.

     

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