Abstract: Objective To explore the effect of salt intake on reactive hyperemia index（RHI） and carotid-femoral pulse wave velocity（cfPWV） in hypertensive patients with different salt sensitivity. Methods Two hundred and ninety-nine hypertensive patients admitted to Xuzhou Central Hospital from June 2016 to August 2022 were included. According to the acute saline loading test, the patients were divided into 3 groups: salt sensitive group（n=146）, intermediate salt sensitive group（n=84） and salt resistant group（n=69）. The urine samples of 24-hour were collected and the salt intake was evaluated based on 24-hour urine sodium levels. According to salt intake, the patients in three groups were divided into three subgroups respectively: low（salt intake＜6 g/d）, medium（6-12 g/d）, and high（＞12 g/d）. Central arterial pressure, cfPWV, and RHI were compared among different subgroups. Pearson correlation was used to analyze the relationship between cfPWV, RHI and salt intake. Multiple linear regression analysis was used to explore the influencing factors of RHI and cfPWV in hypertensive patients. Results RHI in the salt resistant group was higher than that in the intermediate salt sensitive group, and higher than that in the salt sensitive group（1.99±0.42 vs 1.81±0.35 vs 1.68±0.28, F=19.335, P＜0.001）. CfPWVs in the salt resistant group and intermediate salt sensitive group were lower than that in the salt sensitive group （8.90±2.40）,（9.45±2.86） vs（11.00±2.91） m/s, F=16.187, P＜0.001. In the salt resistant group and intermediate salt sensitive group, the RHI of the high salt intake subgroup was lower than that of the low salt intake subgroup（both P＜0.05）. In the salt sensitive group, RHI was lower, while cfPWV was higher in the high salt intake subgroup compared with the middle and low salt intake subgroup（P＜0.001）. Pearson correlation analysis showed that salt intake was negatively correlated with RHI（r=-0.293, P＜0.001）, while positively correlated with cfPWV（r=0.165, P=0.004）. Multiple linear regression analysis showed that the influencing factors of RHI included salt resistance（β=0.371）, intermediate salt sensitivity（β=0.150）, salt intake（β=-0.298）, central systolic blood pressure（β=-0.294）, males（β=-0.146） and hypertension duration（β=-0.135）; the influencing factors of cfPWV included salt resistance（β=-0.221）, intermediate salt sensitivity（β=-0.162）, salt intake（β=0.143）, central pulse pressure（β=0.358）, augmentation pressure（β=0.128）, age（β=0.237） and males（β=0.106）. Conclusions In hypertensives, salt sensitivity exacerbates endothelial dysfunction and arteriosclerosis compared to non-salt sensitivity, and salt sensitivity exacerbates endothelial dysfunction compared to salt resistance. Salt sensitivity and salt intake are independent influencing factors for RHI and cfPWV, and the two factors have an interactive effect on cfPWV.