Abstract: Objective To evaluate the effectiveness and safety of renal denervation（RDN） and pulmonary vein isolation（PVI） for the treatment of hypertension combined with atrial fibrillation by a meta-analysis. Methods PubMed, The Cochrane Library, EMbase, Web of Science, China Biomedical Literature Database, Wanfang Database, and CNKI database were used to search for clinical studies on the treatment of hypertension combined with atrial fibrillation by RDN combined with PVI published from January 2010 to April 2023. The meta-analysis was performed using RevMan5.3 software, and the sensitivity analysis and publication bias analysis were performed using Stata15.1 software. Results Ten literatures with a total of 859 patients were finally included. The results of the analysis showed that the recurrence rate of atrial fibrillation was reduced in the RDN combined with PVI group at 12 months postoperatively compared with the PVI group（RR=0.61, 95%CI 0.51 to 0.72, P＜0.01）, and the difference in the recurrence rate of atrial fibrillation at 24 months postoperatively was not statistically significant. Compared to the PVI group, patients with paroxysmal atrial fibrillation and patients with refractory hypertension had reduced recurrence rates of atrial fibrillation at 12 months postoperatively in the RDN combined with PVI group（RR=0.64, 95%CI 0.51 to 0.81; RR=0.66, 95%CI 0.52 to 0.83）. Compared with the PVI group, the RDN combined with PVI group had lower office systolic and diastolic blood pressures at 12 months postoperatively weighted mean difference（WMD）:-11.58, 95%CI-18.14 to-5.02 mmHg; WMD:-5.90, 95%CI-8.72 to-3.07 mmHg, glomerular filtration rate（GFR） was higher WMD: 14.79, 95%CI 12.95 to 16.63 mL/（min 1.73·m~2）, and blood creatinine, urinary albumin/urinary creatinine decreased at 6 to 12 months postoperatively WMD:-0.27, 95%CI-0.36 to-0.18 mg/dL; WMD-50.26, 95%CI-77.01 to-23.52 mg/g, and interventricular septal thickness, left ventricular end-diastolic internal diameter, and left ventricular mass index decreased at 6 to 12 months postoperatively（WMD:-1.25, 95%CI-1.57 to-0.93 mm; WMD:-2.37, 95%CI-4.63 to-0.11 mm; WMD:-14.59, 95%CI-18.06 to-11.11 g/m~2）（all P＜0.01）. Regarding safety, there was no statistically significant difference in the complication rate between the two groups（RR=1.42, 95%CI 0.74 to 2.75, P=0.29）. Conclusion RDN combined with PVI surgery reduces the 12-month postoperative recurrence rate of atrial fibrillation in patients with hypertension combined with atrial fibrillation, but does not improve the 24-month postoperative recurrence rate of atrial fibrillation, and the combined surgery has better effectiveness and safety.