Abstract: Objective To explore the association between the life’s essential 8 metrics and hyperuricemia. Methods Using a cross-sectional study method, the Kailuan study population who participated in the health examination from 2006 to 2007 was selected as the research subjects. Excluding individuals with any deficiency in the eight elements of life and blood uric acid levels, a total of 92 912 subjects were included. The revised eight elements of life（smoking, physical exercise, dietary health, body mass index, sleeping health, blood pressure, blood sugar and non high-density lipoprotein cholesterol） scale was used for scoring. The subjects were grouped according to the quartile of the score. Hyperuricemia was defined as serum uric acid concentrations of ≥420 μmol/L for men and women. Association between the life’s essential 8 metrics and hyperuricemia was assessed using multiple logistic regression models. Results Among 92 912 coal mine enterprise workers, 79.78% were male, with an average age of（51.5±12.6） years, and 5 997 cases of hyperuricemia were detected, with a detection rate of 6.45%. People of different genders were combined into four groups after grouping by quartiles of the score of the life’s essential 8 metrics. The results of multivariate logistic regression analysis showed that, after adjusted for age, gender, marital status, education level, income level, alcohol consumption, triglycerides, and estimated glomerular filtration rate, compared with the first quartile, the risk of hyperuricemia reduced by 9%（OR=0.91, 95%CI 0.85-0.98, P=0.009）, 26%（OR=0.74, 95%CI 0.69-0.80, P＜0.001） and 36%（OR=0.64, 95%CI 0.59-0.70, P＜0.001） in the second, third, and fourth quartile groups, respectively. For each standard deviation increase in the score of the life’s essential 8 metrics, the risk of hyperuricemia reduced by 2%（OR=0.98, 95%CI 0.98-0.99, P＜0.001）. Stratified analysis showed that compared with the first quartile, the risk of hyperuricemia in the second, third and fourth quartiles reduced by 6%（OR=0.94, 95%CI 0.87-1.01）, 23%（OR=0.77, 95%CI 0.71-0.83） and 32%（OR=0.68, 95%CI 0.62-0.74） for men and reduced by 27%（OR=0.73, 95%CI 0.55-0.96）, 40%（OR=0.60, 95%CI 0.44-0.82） and 55%（OR=0.45, 95%CI 0.30-0.67） for women, respectively. Using the first quartile of the score of the life’s essential 8 metrics for each age group as a reference, the risk of hyperuricemia reduced by 47%（OR=0.53, 95%CI 0.41-0.69）, 45%（OR=0.55, 95%CI 0.44-0.68）, 32%（OR=0.68, 95%CI 0.57-0.82）, 37%（OR=0.63, 95%CI 0.54-0.75）, 25%（OR=0.75, 95%CI 0.63-0.89） in the fourth quartile of the subjects aged ＜35, 35-＜45, 45-＜55, 55-＜65, and ≥65 years, respectively. Conclusion There is a negative correlation between the score of the life’s essential 8 metrics and the risk of hyperuricemia.