Abstract: Objective To explore the influencing factors of maintaining normal serum uric acid in young people. Methods Employees who were under 30 years old and had normal blood uric acid levels at the first physical examination between 2006 and 2016, completed at least two physical examinations and had completed physical examination data were selected from Kailuan study, and finally 13 212 participants were included in the statistical analysis. The follow-up started from the first physical examination and ended at the last physical examination, with maintaining normal blood uric acid levels as the end point. Cox regression model was used to analyze the relationship between related factors and maintaining normal serum uric acid in young people. Results The average baseline age of the included population was（25.7±2.6） years old. A total of 8 974 participants（67.9%） maintained normal serum uric acid during（7.2±3.8） years of follow-up. Cox regression analysis showed that there was a correlation between normal renal function, physical exercise, non-drinking, normal blood pressure, normal blood glucose, normal blood lipids, normal body mass index, higher education and maintenance of normal serum uric acid, with hazard ratio（HR） values（95%CI） of 1.416（1.250-1.603）,1.289（1.209-1.375）,1.239（1.177-1.305）,1.181（1.091-1.279）, 1.158（1.027-1.305）, 1.132（1.070-1.197）, 1.122（1.040-1.210）, 1.114（1.065-1.167）. Conclusion Normal renal function, physical exercise, non-drinking, normal blood pressure, normal blood glucose, normal blood lipid, normal body mass index and higher education are the protective factors to maintain normal serum uric acid in young people from Kailuan study.