血压达标降低高血压患者发生左束支传导阻滞的风险

Achieving blood pressure control targets reduces the risk of left bundle branch block in patients with hypertension

  • 摘要: 目的 研究不同血压达标情况对新发左束支传导阻滞(LBBB)的影响。方法 回顾性分析2006年7月至2007年10月参加健康查体的88 553例开滦员工的基线及随访数据,依据随访初始血压值及高血压病史分为非高血压组及高血压组,进一步将高血压组划分为随访初始血压达标组及随访初始血压不达标组,再依据随访期末血压值对随访初始血压不达标组再次划分为随访期末血压达标组及随访期末血压不达标组。采用多因素Cox比例风险模型分析不同血压达标情况对新发LBBB的影响。对不同年龄、性别进行亚组分析,并分别排除糖尿病、慢性肾脏病(CKD)、心肌梗死或心力衰竭进行敏感性分析。结果 非高血压组50 505例,高血压组38 048例,高血压人群中随访初始血压达标组2 607例,随访初始血压不达标组35 441例,随访初始血压不达标人群中随访期末血压达标组10 658例,随访期末血压不达标组24 783例。经过(10.15±3.44)年的随访,研究人群共发生LBBB 1 010例。非高血压组LBBB的发病密度为0.80/千人年,高血压组为1.58/千人年(Log-Rank检验:P<0.01);高血压人群中随访初始血压达标组为1.04/千人年,随访初始血压不达标组为1.62/千人年;随访期末血压达标组为1.32/千人年,随访期末血压不达标组为1.76/千人年。多因素Cox比例风险模型分析结果显示,以非高血压组为参照,校正各种影响因素后,高血压组发生LBBB的HR(95%CI)为1.42(1.24~1.62);随访初始血压达标组及不达标组发生LBBB的HR(95%CI)分别为0.97(0.66~1.44)和1.45(1.27~1.66);随访初始血压不达标组人群中随访期末血压达标及随访期末血压不达标组发生LBBB的HR(95%CI)分别为1.27(1.04~1.54)及1.53(1.33~1.77)。结论 高血压为新发LBBB的危险因素,降压达标可降低新发LBBB的风险。

     

    Abstract: Objective To investigate the impact of different blood pressure control statuses on newly developed left bundle branch block(LBBB). Methods Aretrospective cohort study was conducted. A total of 88 553 Kailuan employees who underwent health examinations from July 2006 to October 2007 were recruited and categorized into non-hypertension and hypertension groups based on the blood pressure values and hypertension history at the beginning of follow-up. The hypertensive patients were further divided into two groups: initial blood pressure controlled group and initial blood pressure uncontrolled group based on the blood pressure values at the beginning of follow-up. According to the blood pressure value at the end of follow-up, the patients with initial blood pressure uncontrolled were divided into the follow-up blood pressure controlled group and uncontrolled group. The impact of different blood pressure control statuses on the occurrence of newly developed LBBB was analyzed using a multifactorial Cox proportional hazards model. Stratified analyses by age and gender were performed, along with sensitivity analyses excluding participants with diabetes, chronic kidney disease(CKD), heart attack, or heart failure. Results The non-hypertension group comprised 50 505 individuals, while the hypertension group comprised 38 048 individuals. Among the hypertensives, 2 607 patients had controlled blood pressure and 35 441 patients had uncontrolled blood pressure at the beginning of follow-up. Among the patients with uncontrolled initial blood pressure, 10 658 patients had controlled blood pressure and 24 783 patients had uncontrolled blood pressure at the end of follow-up. Over a follow-up period of(10.15±3.44) years, a total of 1 010 cases of LBBB occurred. The incidence density of LBBB was 0.80/1 000 person-years in the non-hypertension group, 1.58/1 000 person-years in the hypertension group(Log-Rank test P<0.001), 1.04/1 000 person-years in the initial blood pressure controlled group, 1.62/1 000 person-years in the initial blood pressure uncontrolled group, 1.32/1 000 person-years in the follow-up blood pressure controlled group, and 1.76/1 000 person-years in the follow-up blood pressure uncontrolled group. The results of the multifactorial Cox proportional hazards model analysis showed that adjusting for various influencing factors, compared with the non-hypertension group, the hazard ratio(HR) of developed LBBB was 1.42(95%CI: 1.24-1.62) in the hypertension group, and which was 0.97(0.66-1.44) and 1.45(1.27-1.66) in the initial blood pressure controlled and uncontrolled group, 1.27(1.04-1.54) and 1.53(1.33-1.77) in the follow-up blood pressure controlled and uncontrolled group, respectively. Conclusion Hypertension serves as a risk factor for newly developed LBBB, and achieving blood pressure control standards can reduce the risk of new-onset LBBB.

     

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