Abstract: Multiple drug intolerance (MDI) usually refers to the intolerable adverse reactions of at least three different types of antihypertensive drugs, while there is no clear immunological mechanism involved. MDI exists objectively in clinical practice, but has been neglected for a long time. The patient's treatment compliance decreased, and blood pressure control was difficult. Patients often return multiple times for repeated consultations, bringing huge psychological and social burden. Analyzing the clinical characteristics of this specific population, sorting out the possible factors leading to MDI, and formulating individualized treatment strategies will help to improve blood pressure control and reduce disease burden.