Abstract:
Objective To explore the association between cumulative life's essential 8 (cumLE8) score and stroke in young adults.
Methods This is a retrospective cohort study. A total of 9 303 participants who consecutively attended 4 physical examinations in the Kailuan Study from 2006 to 2012 were selected. The participants were divided into three groups (T1, T2, T3) according to the tertiles of cumLE8 scores. The physical examination in 2012 was set as the baseline, and follow-up was conducted. The Cox proportional hazards model was used to evaluate the hazard ratio (HR) and 95% confidence interval (CI) of the association between cumLE8 and stroke risk.
Results During a mean follow-up of 9.94 (9.61, 10.15) years, a total of 168 stroke events occurred, among which 106 cases (3.42%) were in Group T1, 44 cases (1.42%) in Group T2, and 18 cases (0.58%) in Group T3. Multivariate Cox proportional hazards regression analysis showed that compared with the Group T1, the HR (95%CI) for stroke in the Group T2 and Group T3 were 0.60 (0.41 to 0.88) and 0.43 (0.24 to 0.79), respectively. When cumLE8 was analyzed as a continuous variable, each increase of 1 standard deviation (6.58) in cumLE8 was associated with a 4% reduction in stroke risk (HR = 0.96, 95%CI: 0.94 to 0.99). In the subtype analysis of stroke, cumLE8 was inversely associated with ischemic stroke, whereas no statistically significant association was observed with hemorrhagic stroke.
Conclusion In the young population, cumLE8 was inversely associated with overall stroke risk, and this association was primarily observed for ischemic stroke rather than hemorrhagic stroke.
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