Abstract: Objective To investigate the effect of personalized dietary intervention on the dietary knowledge, attitude, practice（KAP） and blood pressure control among hypertensive patients, so as to provide an efficient and sustainable plan for the management of hypertension. Methods A randomized controlled trial was carried out among hypertensive patients with iFLYTEK intelligent voice sphygmomanometers in Jieshou, Anhui Province. A total of 3 005 hypertensive patients were recruited at the baseline. After excluding ineligible patients, eligible patients were randomly divided into the intervention group（n=1 190） and the control group（n=1 202）. The general management was maintained in the control group, while the individual-based dietary intervention was additionally applied in the intervention group between August 15, 2021 and February 15, 2022. The evaluation indexes were the blood pressure values of patients in the two groups and the dietary KAP scores in some patients（252 cases in the control group and 277 cases in the intervention group）. Multivariate linear regression analysis was used to analyse the influence factors of the decrease of systolic and diastolic blood pressure in the intervention group. Results After 6 months of intervention, the systolic blood pressure（SBP） and diastolic blood pressure（DBP） decreased by（9.1±18.8） and（3.3±12.5） mmHg respectively in the intervention group, while which decreased by（5.7±17.6） and（2.2±12.8） mmHg respectively in the control group. There was significant difference in the decrease of systolic blood pressure between the two groups（t=5.554, P＜0.05）. After 6 months of intervention, the increases of KAP scores of the intervention group were higher than those of control group（P＜0.05）. Multivariate linear regression analysis showed that the change of dietary practice score was positively correlated with the decrease of systolic blood pressure（β=0.19, P=0.03）, and body mass index（BMI） was positively correlated with the decrease of diastolic blood pressure（β=0.20, P=0.03）. Conclusion After 6 months of personalized dietary intervention, the blood pressure of hypertensive patients significantly decreased, and the scores of dietary KAP related to hypertension were improved.