Abstract: Objective To investigate the interactions between DNA methylation of angiotensin Ⅱ type 1 receptor（AT1 R）gene and environmental factors in coronary atherosclerotic heart disease in community residents. Methods A total of 8720 residents were enrolled from April 2014 to September 2015 in Cities of Fuqing,Changle and Nan′an,Fujian Province. The epidemiological investigations and laboratory tests were conducted. The community-based case-control study method was used to analyze the DNA methylation of AT₁ R gene in saliva samples in patient and control groups using the high-resolution melting curve（HRM）kit. Regression model and Delta method were used to analyze the interactions of AT1 Rgene methylation with environmental factors. Results The multivariate Logistic regression analysis showed that the environmental risk factors for coronary atherosclerotic heart disease were higher body mass index（BMI）（OR=1.712,95% CI 1.289-2.274）and central obesity（OR=1.353,95% CI1.003-1.825）,while weekly drink≤ 3 times（OR =0.463,95% CI0.245-0.876）and physical exercise（OR=0.804,95% CI0.686-0.943）were the protective factors. After adjusted for demographic and environmental factors,lower level of AT1 Rgene methylation was a risk factor for coronary atherosclerotic heart disease. Fragmentation analysis showed that the degree of AT1 Rgene methylation was associated with environmental factors（central obesity）. The interactions between the two groups was statistically significant（U=2.105,P=0.035）with attribution ratio（AP）of 0.579% and relative excess risk due to interaction（RERI）of 4.86. Conclusion Coronary atherosclerotic heart disease could be the result of the interaction of environmental factors and DNA methylation and other epigenetic factors. The methylation degree of AT₁ Rgene and central obesity may have additive interaction with coronary atherosclerotic heart disease.