Abstract: Objective To determine risk factors for in-hospital mortality in patients with acute aortic dissection（AAD）and set up a risk prediction model. Methods A retrospective analysis was performed on the clinical data from 196 patients with AAD who were hospitalized in General Hospital of Chinese People’s Armed Police Force between January 2004 and May 2016. Univariate and multivariate Logistic regression analyses were used to identify independent risk factors for in-hospital mortality. Risk prediction model was set up.Hosmer-Lemeshow goodnessof-fit test and the area under the receiver operating characteristic（ROC）curve were used to determine the model’s predictive ability for in-hospital mortality in patients with AAD. Results In 196 patients with ADD,36 patients died during their hospitalization,and the in-hospital mortality rate was 18.4%.Multivariate Logistic regression analysis showed that independent risk factors for in-hospital mortality in patients with AAD included age≥65years（OR=4.57,P=0.010）,hypotension（OR=9.58,P=0.001）,acute kidney injury（OR=11.42,P=0.001）,ischemic complications（OR=6.35,P=0.001）,neurological symptoms（OR=7.60,P=0.020）and type A dissection（OR=7.59,P=0.001）. The Pvalue for Hosmer-Lemeshow goodness-of-fit test was 0.18 and the area under the ROC curve was 0.92. Conclusion Independent risk factors for in-hospital mortality in patients with AAD were age≥65years,hypotension,acute kidney failure,ischemic complications,neurological symptoms and type A dissection.