理想心血管健康行为和因素与血尿酸水平的关系

The relationship between ideal cardiovascular health behaviors and factors with serum uric acid

  • 摘要: 目的探讨理想心血管健康行为和因素与血尿酸水平的关系。方法采用横断面研究方法,以参加2006-2007年度开滦集团公司健康查体的职工为研究对象,排除7项理想心血管健康行为和因素指标中任意一项不全或缺失者,以及血尿酸资料缺失者。最终纳入95 332例,其中男性760 44例,年龄(52.1±12.6)岁,女性19 288例,年龄(48.7±11.5)岁,进行统一问卷调查和血生化检查,依据美国心脏协会定义的理想心血管健康行为和因素,采用Logistic回归分析理想心血管健康行为和因素对血尿酸水平的影响。结果随着理想心血管健康行为和因素项数的增加,男性和女性的尿酸水平呈下降趋势,各组间比较差异有统计学意义(均P<0.05)。多因素Logistic回归分析表明,随着理想心血管健康行为和因素项数的增多,高尿酸血症的检出率逐渐下降;校正年龄、教育、饮酒、家庭人均月收入、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、高敏C反应蛋白后,无论性别,与0、1项者相比,2、3、4和≥5项者的理想心血管健康行为和因素者高尿酸血症的检出率呈逐渐降低趋势,女性OR值分别为:0.95(0.75~1.22)、0.76(0.60~0.97)、0.69(0.53~0.89)、0.63(0.48~0.84);男性分别为:0.86(0.79~0.93)、0.69(0.64~0.75)、0.57(0.52~0.63)、0.62(0.54~0.71)。结论随着理想心血管健康行为和因素项数的增加,高尿酸血症的检出率呈下降趋势。

     

    Abstract: Objective To investigate the effects of ideal cardiovascular health behaviors and factors(ICHBF)on the levels of serum uric acid(UA). Methods The Kailuan staff who participated in the 2006-2007 health examination were investigated with a cross-sectional study method. In total,95 332subjects(76 044 males,aged 52.1±12.6years old and 19 288 females,aged 48.7±11.5years old),with complete data on serum UA and cardiovascular health behaviors and factors were finally recruited. Questionnaires and blood biochemical examinations were carried out for all subjects. According to the American Heart Association(AHA)definition of ICHBF,multivariate Logistic regression analysis was used to assess the effects of ICHBF on the levels of serum UA. Results With the increasing number of ICHBF,serum UA levels in both males and females exhibited a declined tendency,with significant differences observed in both groups. Multiple Logistic regression analysis revealed that the risk for hyperuricemia(HUA)was reduced gradually with the increasing number of ICHBF. Further,in both genders,the risk for HUA was declined with the increase of ICHBF(2,3,4and≥5),compared with the subjects who had none or only one ICHBF,with the corresponding odds ratios of being 0.95(95%confidence interval:0.75-1.22),0.76(0.60-0.97),0.69(0.53-0.89),0.63(0.48-0.84)in females and 0.86(0.79-0.93),0.69(0.64-0.75),0.57(0.52-0.63),0.62(0.54-0.71)in males,respectively,after adjusting for age,educational level,alcohol drinking,income,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol,creatinine and high-sensitive C-reactive protein. Conclusion With the increasing number of ICHBF,the risk of HUA reduces gradually.

     

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