Abstract: ObjectiveTo analyze clinical characteristics in 653 patients with acute aortic dissection（AAD）,and explore the risk factors associated with hospital death in these patients.MethodsThe clinical data of 653 patients with AAD from the first affiliated hospital of Xinjiang medical university between 2002 and 2011 were retrospectively analyzed,and the mortality of AAD patients was calculated. The correlation between gender, comorbidity, clinical symptoms and signs, complications, therapies and hospital mortality of AAD was explored.ResultsAmong 653 patients with AAD, the average age of onset was （51.7±13.5） years old, the male-to-female ratio was 3.11 to 1.00, and the ratio of Han nationality to national minority was 2.46 to 1.00.Hypertension or increased blood pressure on admission was presented in 81.2% of all the subjects.Debakey type Ⅰ, Ⅱ and Ⅲ were identified in 31.7%, 8.3% and 60.0% of all the subjects respectively. The overall hospital mortality of AAD was 12.7% （30.0% for Debakey typeⅠ, 7.4% for Debakey type Ⅱ, 4.3% for Debakey type Ⅲ）.Multivariate Logistic regression analysis showed that acute renal dysfunction （OR=3.01）, hydropericardium （OR=5.67）, local limbs ischemia （OR=17.38）, Debakey typeⅠ（OR=4.93）, chest pain （OR=4.66） and neurologic symptoms（OR=4.61） were risk factors for hospital death for patients with AAD （all P＜0.05）.ConclusionsThe onset age of patients with AAD in Xinjiang was getting younger. 81.2% of the hospitalized patients with AAD suffered from hypertension or increased boold pressure.Chest pain, acute renal dysfunction, hydropericardium, neurologic symptom, local limbs ischemia and Debakey type Ⅰ were independent risk factors for hospital death for patients with AAD.