Abstract: Objective To explore the association of sedentary time with cardiocerebral deaths. Methods A total of 12 608 community residents aged 35 years or above in Jiangxi Province who took part in "the study on prevalence of major cardiovascular diseases and key techniques in China" during 2013 and 2014 were enrolled in this prospective, observational cohort study. Sedentary time was obtained through baseline questionnaire, and all death events were collected by telephone follow-up, information reported from the departments of public health in township health centers and village doctors, and death surveillance system of Jiangxi Center for Disease Control and Prevention. Cox proportional hazard regression model was used to evaluate the association of sedentary time with cardiocerebral deaths. Results A total of 11 744 participants were included in final analysis. During an average 5.4 years of follow up（63 297.8 person-years）, 796 all-cause deaths occured, including 373 cardiocerebral deaths. The difference of cardiocerebral death rate were statistically significant in three groups of ＜6 h/d（2.9%）, 6-8 h/d（3.9%） and ＞8 h/d（5.4%）, respectively（χ~2=13.57, P＜0.01）. Kaplan-Meier curve showed that there was a significant difference in the cumulative mortality among three groups（Log-Rank χ~2=17.27, P＜0.01）. Cox regression analysis showed that after adjusting for relevant confounding factors, older age, high body mass index（BMI）, male, rural residents, unemployment and long sedentary time were risk factors for cardiocerebral deaths. Compared with the ＜6 h/d group, the risk of cardiocerebral deaths increased by 68.3%（HR=1.683, 95%CI 1.186-2.388） for participants with sedentary time of ＞8 h/d. Conclusion Long sedentary time independently increases the risk of cardiocerebral deaths.