Abstract: Objective To investigate the relationship between lipoprotein-associated phospholipase A2（LP-PLA2）and brachial-ankle pulse-wave velocity（baPWV）and ankle-brachial index（ABI）in patients with hypertension.Methods A total of 144 hypertensives were recruited as hypertension group,of which 20 patients were at low risk,30 at middle risk,32 at high risk and 62 at very high risk. And 30 normotensives served as control. The blood lipid,fasting blood glucose,2-hour postprandial blood glucose were examined. The level of LP-PLA2 was detected by enzyme-linked immunosorbent assay（ELISA）method,and baPWV and ABI were measured by arteriosclerosis detector. The levels of LP-PLA2,baPWV and ABI were compared among hypertensives with different risk stratification and control group. The correlation between LP-PLA2 and baPWV or ABI was analyzed. Results The levels of LP-PLA2 and baPWV in hypertension group were significantly higher than those in the control group（268.62±87.13）vs（187.64±49.01）μg/L,（1878±362）vs（1398±239）cm/s,P＜0.01. While ABI in hypertension group was lower than that in control group（1.13±0.07 vs 1.19±0.06,P＜0.01）. The LP-PLA2 and baPWV in the very-high-risk group were higher,while ABI was lower than those in the high-risk group,middle-risk group and the low-risk groupLP-PLA2:（289.19±95.37）vs（253.70±80.38）,（233.37±55.14）,（219.62±50.55）μg/L;baPWV:（1997.05±380.54）vs（1772.56±292.27）,（1738.33±224.45）,（1569.80±200.66）cm/s;ABI:1.10±0.07 vs 1.14±0.05,1.15±0.04,1.17±0.04;all P＜0.05. The level of LP-PLA2 was positively correlated with baPWV（r=0.857,P＜0.01）and negatively correlated with ABI（r=-0.436,P＜0.01）in hypertensive patients. Conclusion LP-PLA2 and baPWV were increased and ABI was decreased in very-high-risk hypertensives. LP-PLA2 was correlated positively with baPWV,while correlated negatively with ABI.