原发性高血压与结直肠肿瘤相关性的荟萃分析

The correlation between essential hypertension and colorectal tumors: a meta-analysis

    摘要
  • 摘要:
    目的 采用荟萃分析系统评价原发性高血压与结直肠肿瘤间的关系。
    方法  在中国知网、万方数据库、维普数据库、中华医学期刊数据库、PubMed、Web of Science、The Cochrane Library、Embase数据库检索建库至今发表的关于原发性高血压与结直肠肿瘤关系的中英文文献。对纳入的文献进行信息提取和质量评价，应用 RevMan 5.3 软件进行统计学分析，绘制森林图，同时进行敏感性和发表偏倚检测。
    结果  最终纳入文献6篇，包括5 530 369名参与者。荟萃分析结果显示：原发性高血压患者发生结直肠肿瘤的风险增加（OR=1.71，95%CI 1.65～1.77，P＜0.001）。敏感性分析显示结果稳定性较好，漏斗图提示无发表偏倚。
    结论  原发性高血压与结直肠肿瘤相关。

     

    Abstract:
    Objective  To evaluate the relationship between essential hypertension and the risk of colorectal tumor through a meta-analysis.
    Methods Chinese and English literatures about the relationship between essential hypertension and colorectal tumor published so far were searched in China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, Chinese Medical Journal Database, PubMed, Web of Science, The Cochrane Library and Embase Database. Information extraction and quality evaluation were carried out on the included documents, statistical analysis was carried out by using RevMan 5.3 software, forest map was drawn, and sensitivity and publication bias were detected.
    Results Six articles including 5 530 369 participants were finally included. Meta-analysis showed that the risk of colorectal tumor in patients with essential hypertension increased (OR=1.71, 95%CI 1.65–1.77, P＜0.001). The results of sensitivity analysis showed that the results were stable, and the publication bias analysis showed that there was no significant publication bias.
    Conclusion There is a correlation between essential hypertension and colorectal tumor.

     

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