糖尿病人群高血压的发病率及影响因素

Incidence of hypertension and influencing factors in diabetes patients

  • 摘要: 目的探讨糖尿病人群的高血压发病率及影响因素。方法选择2006-06-2007-10健康体检的开滦集团在职及离退休职工101510人,空腹血糖≥7.0或<7.0mmol/L但已确诊为糖尿病,正在使用降糖药物且血压<140/90mmHg的糖尿病者作为观察人群。于12~39(25.6±4.9)月后进行第二次健康体检,测量血压并计算发病率,用Logistic回归模型分析影响高血压发病的因素。结果在基线正常血压的观察对象2367人中,于第2次体检时有908例进展为高血压,糖尿病人群高血压的累积发病率为38.4%,男性高于女性(40.2%比31.0%,P<0.01)。<40、40~<50、50~<60和≥60岁年龄组,高血压发病率分别为28.9%、34.0%、40.2%和43.6%。校正相关因素后,影响糖尿病人群进展为高血压的危险因素包括年龄、男性、体质量指数(BMI)、腰围、收缩压和尿酸(OR值分别为1.167、1.382、1.490、1.220、2.126、1.334,均P<0.05);男性高血压发病的影响因素有年龄、BMI、收缩压、三酰甘油和尿酸(OR值分别为1.141、1.484、2.116、1.239、1.291,均P<0.05);女性高血压发病的影响因素有年龄、腰围和收缩压(OR值分别为1.409、2.131、2.208,均P<0.05)。结论糖尿病人群高血压的累积发病率随年龄增加而升高并存在性别差异。影响其进展为高血压的危险因素包括年龄、男性、BMI、腰围、收缩压和尿酸;其中年龄、BMI、收缩压、三酰甘油和尿酸影响男性高血压发病,年龄、腰围和收缩压则影响女性。

     

    Abstract: Objective To explore the incidence and influencing factors of hypertension in diabetes patients. Methods The data was derived from 101 510 active and retired employees of Kailuan Group, who took health examination from June, 2006 to October, 2007. Those who with fasting plasma glucose≥ 7.0 mmol/L or those treated diabetes patients with fasting plasma glucose <7.0 mmol/L and blood pressure<140/90 mm Hg were observed. 12 to 39(mean 25.6±4.9) months later, the secondary health examination was carried out. Their blood pressures were measured and the incidence of hypertension was calculated. The influencing factors of hypertension were analyzed by Logistic regression model. Results In the second health examination, there were 908 of 2367 individuals with normotension in the first examination developed into hypertension. The hypertension cumulative incidence was 38.4%, which was higher in males than in females (40.2% vs 31.0%, P<0.01), and in the four age groups (<40, 40-<50, 50-<60 and ≥60) were 28.9%, 34.0%, 40.2% and 43.6%, respectively. After adjustment for other risk factors, binary logistic regression showed that the risk factors of hypertension for diabetes patients were age, male, body mass index(BMI), waist circumference, systolic blood pressure(SBP) and uric acid(respectively, OR 1.167, 1.382, 1.490, 1.220, 2.126, 1.334, P<0.05). Hypertension risk factors for males were age, BMI, SBP, triglycerides and uric acid(respectively, OR 1.141, 1.484, 2.116, 1.239, 1.291, P<0.05), and these for females were age, waist circumference, and SBP (respectively, OR 1.409, 2.131, 2.208, P<0.05). Conclusions Incidence of hypertension in diabetes patients increases with age and differs in genders. Age, male, BMI, waist circumference, SBP, and uric acid are risk factors of hypertension for diabetes patients. Age, BMI, SBP, triglycerides and uric acid affect the hypertension prevalence of males, while age, waist circumferenceand and SBP affect females.

     

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