Abstract:
Background Although great advances have been made in prevention and treatment of CVD through drug therapies and other procedures,diet and lifestyle modification remain the foundamental aspects in clinical inter vention for prevention and treatment of hypertension.Objective The purpose of this research is to investigate the impact of variour dietary patterns on traditional cardiovascular risk factors in essential hypertensives in Beijing area. Food frequency questionnaire (FFQ) survey was carried out in a cohort of 424 patients of hypertension.Methods All participants completed an FFQ.Baseline clinical data (height,weight,waist circumference and biochemical da- ta) were collected by physical examination and biochemical assay.According to their dietary patterns,three dietary pattern were delineated:vegetarian diet(n=95),meat dominant diet(n=133) and balanced diet(n=196).Clinical and biochemical data were compared between them,and analyzed by multivariate logistic regression models.Results 1)The morbidity of obesity in meat dominant people was significant higher than vegetarians (46.6% vs 21.7%,P< 0.01) and balanced diet (46.6% vs 30.0%,P<0.01).The rate of overweight plus obesity was also markedly higher in meat dominant than vegetarians (90.5% vs 61.4%,P<0.01) and balanced diets (90.5% vs 72.9%,P< 0.01).2)Comparing with vegetarians,body mass index (BMI),waist circumference,and the level of serum creat- inine and uric acid (UA) were significantly higher of carnivores and balanced diets (P<0.01 and P<0.05).Sub- jects using balanced diets had a markedly lower value of BMI,waist circumference,serum ereatinine and UA than that in meat dominant(P<0.01).3)Comparing with vegetarians and balanced diets,subjects of meat dominant had significantly higher level of brachial artery pulse pressure,serum alanine aminotransferase (ALT) and triglyceride (TG) (P<0.01);their high-density lipoprotein cholesterol (HDL-C) level was notably lower (P<0.01) at the same time.But these parameters did not show any significantly difference between vegetarians and balanced diets. 4)The morbidity of metabolic syndrome (MS) in meat dominant cohort was significant higher than vegetarians (74.30% vs 53.7%,P<0.01) and balanced diets (74.3% vs 62.4%,P<0.01),with no difference between vege- tarians and balanced diets.5)Logistic regression analysis indicated that:dietary patterns was the independent influ- ential factor for HDL-C(OR=2.118,P=0.008) and waist circumference (OR=5.376,P=0.017) in patients with essential hypertension.Conclusions 1)Dietary patterns are significantly correlated with the morbidity of over- weight and obesity of essential hypertensives.2)Consuming a diet rich in vegetables,fruits and carbohydrate deft nitely improve the level of HDL-C and waist circumference of hypertensives,decrease the prevalence of MS.