Relationship Between PPAR γ₂ Gene Pro12Ala Polymorphism Hypertension and Blood Lipids

Objective Relationship between peroxisome proliferator-activated receptor（PPAR） γ-2 gene Pro12Ala polymorphism and hypertension, polymorphism and blood lipids were studied. Methods PPAR γ-2-Pro12Ala gene variant was detected using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） and direct sequencing in 112 healthy controls and 125 hypertensives. Results The distribution of genotype frequencies and allele frequencies of PPAR γ-2 gene-Pro12Ala polymorphism in hypertensives was similar to that in controls. The Pro12Ala variant was not associated with hypertension. However, the level of LDL-cholesterol was significantly higher in PA/AA genotype （3.53±0.59） mmol/L than that in PP genotype （2.47±0.45） mmol/L, （P＜0.05）. Conclusion In Hubei Han population, Pro12Ala polymorphism of PPAR γ-2 gene is associated with dyslipidemia in hypertensives.