Association of T786C Polymorphism of Endothelial Nitric Oxide Synthase Gene with Essential Hypertension and the Effect of Valsartan

Objective To investigate the association of the T786C polymorphism of endothelial nitric oxide synthase （eNOS） gene with the antihypertensive effects of valsartan in hypertensive patients. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of eNOS gene in 167 normotensive controls and 267 hypertensive patients. 109 patients were treated with valsartan for 4 weeks. Results The frequencies of C allele and CCCT genotype in EH were significantly higher than in control group; DBP of patients with C allele of eNOS gene was （99.66±6.59） mmHg, higher than that of TT genotype（97.32±7.44） mmHg. Average reduction in SBP and DBP were significantly greater in patients with CT and CC than in TT genotype. Conclusion eNOS T786C gene polymorphism can be used as one of adjunctive indicators for predicting the response effects of Angiotensin Ⅱ type 1 receptor antagonist in hypertensive patients.