The Baroreflex Sensitivity of the Essential Hypertensive

ObjectiveTo investigate the baroreflex sensitivity （BRS） of the essential hypertensive（EH） and its possible related factors.MethodsThe blood sugar and lipid profile were measured, BRS were calculated by oblique position method, when blood pressure and heart rate were recorded simultaneously.Blood flow-mediated endothelium relaxation function（FMD） was examined in the brachial artery by ultrasonography.Results（1） BRS in patients with hypertension was lower than that in normal control（NC）（6.9±7.3 vs 13.9±3.6 ms/mm Hg, P＜0.01）, and was also lower than that in the renal hypertensive（RH）（6.9±7.3 vs 12.2±6.2 ms/mm Hg, P＜0.01）.However, BRS has a trend of declination with the grades of hypertension.BRS was higher in patients of first stage EH than that of the third stage EH（10.2±4.0 vs 5.4±4.8 ms/mm Hg, P＜0.01）, second grade higher than that of the third grade EH（7.6±2.4 vs 5.4±4.8 ms/mm Hg, P＜0.01）; （2） BRS in EH complicated with hypercholesterolemia is lower than EH without hypercholesterolemia （2.2±4.7 vs 7.2±6.4 ms/mm Hg, P＜0.01）; （3）FMD correlated with the BRS in EH（r=0.565, P＜0.01）, as well as in RH （r=0.573,P＜0.05） and in NC（r=0.610, P＜0.05）.ConclusionThe reduced baroreflex sensitivity may be one of the mechanism of the developement of the essential hypertension.Anti-hyperlipidemia therapy is beneficial to hypertensive patients via promotion of BRS.Blood-mediated endothelium relaxation function apparently related with the BRS.