The Changes of Plasma Natriuretic Peptides with Reversal of Left Ventricular Hypertrophy in Hypertension Patients

ObjectiveTo investigate the dynamic changes of natriuretic peptides in associated with reversal of left ventricular hypertrophy （LVH） in essential hypertension patients.MethodsWe studied 96 consecutive essential hypertension patients （49 men and 47 women; average age 55.2±8.7 years ） with LVH.LVH was reversed in 50 patients（LVH reversal group, 28 men and 22 women; average age 56.1±8.6 years ） while 46 patients LVH was sustained after 3 years medical treatment （LVH sustained group, 25 men and 21 women; average age 55.1±8.2 years ）.Plasma atrial and brain natriuretic peptides （ANP, BNP） were measured by radio-immunoassay and immunoradiometric assay.Forty healthy normatersive persons, age and gender-matched, served as controls.ResultsPlasma levels of ANP and BNP in LVH sustained group were significantly elevated compared with LVH reversal group （ANP:60.1±3.4 vs 12.6±2.1 pg/mL, P＜0.01; BNP:68.9±9.2 vs 13.2±2.0 pg/mL, P＜0.01）. No difference in ANP and BNP levels between LVH reversal group and healthy persons with normal blood pressure was found （P＜0.01）.ConclusionANP and BNP levels are closely related to LVH which could be decreased to normal level after LVH reversal.