Metabolic characteristics in hypertensive patients with obstructive sleep apnea syndrome

Objective obstructive sleep apnea syndrome（OSAS） is a well-recognized risk factor for cardiovascular disorders and is related to metabolic syndrome.The aim of this study was to investigate the characteristics of metabolism in hypertensive patients with OSAS.Methods Five hundred fifty patients were enrolled.The subjects underwent polysomnography.According to apnea-hypopnea index（AHI）,the patients were divided into four groups.Ninety-four essential hypertension（EH） only patients served as control.There were 157 patients in mild,126 in moderate and 173 in severe OSAS+EH group.AHI,body mass index（BMI）,blood pressure,fasting serum total cholesterol（TC）,HDL-C,LDL-C,triglycerides（TG）,glucose（G）,insulin（INS）,uric acid（UA） and homocysteine（Hcy） were examined.Results Patients in OSAS+EH groups were older,had higher levels of BMI （29.9±3.7） vs（27.5±2.9）kg/m2,AHI,FINS and UA （374.1±92.2） vs（342.1±91.0）μmol/L than those in control（P＜0.05）.Patients in severe OSAS+EH group had lower levels of HDL-C,MSpO2 （69.9±11.8）% vs（85.0±10.3）%,P＜0.05 than those in control.Patients in severe OSAS+EH group had higher levels of 2HPINS than those in mild and moderate group （P＜0.05）.The levels of TG,HDL-C,MS,UA in severe OSAS+EH were higher than in EH.UA in OSAS+EH was higher than in EH.There were significant differences in two or three measures among the four groups.Conclusion Hypertensive patients with severe OSAS have more metabolic disfunctions.