Predictive value of plasma long noncoding RNA associated with microvascular invasion in hepatic carcinoma for preeclampsia

Objective To investigate the expression of long noncoding RNA associated with microvascular invasion in hepatic carcinoma（LncRNA MVIH） in the plasma of patients with preeclampsia（PE） and to explore its predictive value for PE either alone or in combination with other indicators. Methods Plasma samples were selected from patients in the prospective pregnancy cohort of our research group at 7-16 weeks of gestation between December 2016 and April 2018. Patients were divided into PE and control groups according to pregnancy outcome. Real-time polymerase chain reaction（real-time PCR） was used to detect the expression level of plasma LncRNA MVIH. The clinical data of maternal pregnancy were collected, and the univariate analysis was conducted on all statistical indicators. Logistic regression analysis was performed on indexes with statistical differences. The receiver operating characteristic（ROC） curve was used to evaluate the predict value of each independent risk factor and regression model. Results Before 16 weeks of pregnancy, body mass index（BMI）, systolic blood pressure, diastolic blood pressure, mean arterial pressure（MAP）, white blood cell（WBC）, hemoglobin, alanine aminotransferase（ALT）, uric acid（UA） and urine protein were positively correlated with PE, while LncRNA MVIH was negatively correlated with PE. Independent markers with predictive value were LncRNA MVIH, UA, WBC, ALT, and urine protein, with the area under curve（AUC） in predicting PE of 0.763, 0.741, 0.663, 0.666, and 0.601, respectively. After the combination, the AUC increased to 0.890 with sensitivity, specificity and accuracy of 86.4%, 83.1% and 84.7% respectively. Conclusion Plasma LncRNA MVIH is closely related to PE and has predictive value for PE. The combination of LncRNA MVIH, UA, WBC, ALT, and urine protein has a greater predictive value.