The correlation between essential hypertension and colorectal tumors: a meta-analysis

Objective  To evaluate the relationship between essential hypertension and the risk of colorectal tumor through a meta-analysis.

Methods Chinese and English literatures about the relationship between essential hypertension and colorectal tumor published so far were searched in China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, Chinese Medical Journal Database, PubMed, Web of Science, The Cochrane Library and Embase Database. Information extraction and quality evaluation were carried out on the included documents, statistical analysis was carried out by using RevMan 5.3 software, forest map was drawn, and sensitivity and publication bias were detected.

Results Six articles including 5 530 369 participants were finally included. Meta-analysis showed that the risk of colorectal tumor in patients with essential hypertension increased (OR=1.71, 95%CI 1.65–1.77, P＜0.001). The results of sensitivity analysis showed that the results were stable, and the publication bias analysis showed that there was no significant publication bias.

Conclusion There is a correlation between essential hypertension and colorectal tumor.