Effect of hazard analysis and critical control point principle-based treatment regimen on neurological, cognitive, and limb motor functions in patients with hypertensive intracerebral hemorrhage

Objective To explore the effects of a rehabilitation treatment program based on the principles of Hazard Analysis and Critical Control Points (HACCP) on neurological function, cognitive function and limb motor function in patients with hypertensive intracerebral hemorrhage. Methods A total of 420 patients with hypertensive intracerebral hemorrhage who received medication in the Department of Neurology, Wuhan Fourth Hospital from June 2020 to June 2023 were enrolled. Using a multi-level blinding mechanism, the patients were randomly divided into a conventional treatment group and an HACCP group, with 210 cases in each group. The changes in neurological, cognitive and limb motor functions between the two groups before and after treatment were compared. Multivariate logistic regression analysis was used to screen the influencing factors of rehabilitation treatment efficacy in the patients. Results After treatment, compared with the conventional treatment group, the HACCP group showed significant increases in the Fugl-Meyer Assessment (FMA) score (73.24±3.28) vs (62.90±2.82), t=34.640, Functional Independence Measure (FIM) score (106.75±17.82) vs (99.64±20.03), t=52.491, Barthel Index (BI) score (73.39±4.47) vs (59.76±3.18), t=36.006, Mini-Mental State Examination (MMSE) score (Chinese version) (24.16±1.28) vs (22.72±1.20), t=11.893, and general health score (58.23±6.61) vs (49.65±5.94), t=13.991, while the National Institutes of Health Stroke Scale (NIHSS) score was significantly decreased (4.72±1.19) vs (7.53±1.58), t=20.587 (all P＜0.001). In addition, the HACCP group had a higher total effective rate of rehabilitation treatment than the conventional treatment group (89.05% vs 71.90%, χ²=9.639) and a lower incidence of complications (3.33% vs 18.57%, χ²=24.999, both P＜0.01). Results of multivariate logistic regression analysis indicated that NIHSS score at admission OR=2.282, 95%CI (1.365–3.813), age OR=1.857, 95%CI (1.221–2.825), intracerebral hemorrhage location OR=5.836, 95%CI (3.141–10.841), body mass index OR=1.314, 95%CI (1.026–1.682) and complications OR=3.979, 95%CI (2.113–7.494) were the influencing factors of rehabilitation treatment efficacy in the patients (P＜0.05). Conclusion The HACCP-based rehabilitation treatment program can effectively improve neurological function, cognitive function and limb motor function in patients with hypertensive intracerebral hemorrhage.