Objective To explore the correlation between metabolic abnormalities in essential hypertension patients and elevated plasma fibrinogen levels. Methods: Retrospective analysis of clinical data of 1 043 patients attending the geriatric clinic of the First Hospital Affiliated with Fujian Medical University. According to the presence or absence of hypertension and metabolic component abnormalities, they were divided into control group (no EH and metabolic abnormalities). The EH group alone and the EH group combined with 1 / 2 / 3 metabolic component abnormalities were subsequently included in the eligible study subjects according to the criteria of the respective groups. The control group consisted of 77 cases, the group with isolated EH consisted of 194 cases, and the groups with EH combined with abnormalities in one, two, or three metabolic components were 352, 316, and 104 cases, respectively.In order to further clarify the impact of different types of metabolic abnormalities on Fib levels in patients with EH, the EH group was subdivided into sub-groups based on the presence of one specific metabolic abnormality, including EH with obesity, EH with glucose metabolism abnormalities, and EH with lipid metabolism abnormalities. Utilize multiple linear regression analysis to study the correlation between Fib levels and various indicators in patients with EH, while also considering other factors. Using hyperfibrinogenemia as dependent variable and multiple metabolic abnormalities as independent variable, the relationship between multiple metabolic abnormalities and hyperfibrinogenemia was analyzed by binary logistic regression analysis.Results: compared to the control group and patients with isolated EH, patients with EH who also had metabolic abnormalities exhibited elevated Fib levels EH combined with 1 to 3 metabolic component abnormalities:(3.22 ± 0.93), (3.31 ± 0.97), (3.49 ± 1.09) g/L vs control (2.83 ± 0.59) g/L, EH (2.97 ± 0.71) g/L, F = 10.4, P＜0.001. The levels of vitriol in patients with EH combined with simple dysglycemia and EH combined with simple dyslipidemia were higher than those in patients with simple EH (3.37 ± 0.91, (3.26 ± 0.92) vs (2.97 ± 0.71) g/L, F = 5.75, P＜0.05. Binary logistic regression analysis was performed with hyperfibrinogenemia or not as dependent variable.After adjusting for relevant variables, the risk of hyperfibrinogenemia was 2.36 times higher in patients with EH and glucose abnormalities alone (OR＝2.36, 95%CI 1.03 to 5.44). The risk of hyperfibrinogenemia was 5.18 times (OR＝5.18, 95%CI 1.47 to 18.26) and 5.51 times (OR＝5.51, 95%CI 1.32 to 23.10) in patients with two and three metabolic abnormalities, respectively, compared with the control group. It was 3.11 times (OR＝3.11, 95%CI 1.52 to 6.37) and 3.14 times (OR＝3.14, 95%CI 1.23 to 8.02) of patients with simple EH. Multiple linear regression analysis showed that serum fibrinogen level was significantly correlated with gender (β = 0.201), age (β = 0.011), white blood cell count (β = 0.062), high-sensitivity C-reactive protein (β = 0.068), fasting plasma glucose (β = 0.013), and total bilirubin (β = −0.026) were positively correlated (P ＜ 0.05).
Conclusions In EH patients , when metabolic abnormalities are combined, fibrinogen levels are elevated, and fibrinogen is elevated with the number of metabolic abnormities. The effect of blood sugar on fibrinogen elevation is more prominent.
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