Advances in research on the association between migraine and elevated blood pressure and its mechanisms

Migraine is a common chronic neurological disorder characterized by recurrent attacks, it is susceptible to multiple influencing factors such as sleep, emotions, and diet. Migraine attacks triggered by blood pressure fluctuations, particularly elevated blood pressure (hypertension), is a clinical phenomenon that deserves attention. The primary underlying mechanisms involve dysregulation of the autonomic nervous system (ANS), overactivation of the renin-angiotensin system (RAS), and abnormal metabolism of neurotransmitters/neuromodulators such as calcitonin gene-related peptide (CGRP), serotonin (5-HT), and endothelin-1 (ET-1). Clarifying the correlation between migraine attacks and blood pressure elevation, along with its mechanisms, is crucial for implementing appropriate blood pressure management strategies to help control migraine episodes.