A case of adolescent paroxysmal hypertension caused by heterozygous deletion of 15q26.2-q26.3

The association between a de novo heterozygous deletion at chromosome 15q26.2-q26.3 and adolescent onset paroxysmal secondary hypertension along with multiple system phenotypes was investigated, through whole-genome sequencing of a 17-year-old female proband and her parents and brother, as well as copy number variations (CNV) analysis and family cosegregation studies.